Association Study of the Relationship between Endometriosis and Polymorphism of p53 Codon 72.

Hur,  Sung Eun; Shim,  Soung Shin; Lee,  Kyung Soon; Moon,  Hye Sung; Yu,  Han Ki; Chung,  Hye Won

Original Article

Korean Journal of Fertility and Sterility 2002;29(4):311-316.
Published online December 1, 2002.

Association Study of the Relationship between Endometriosis and Polymorphism of p53 Codon 72.

Sung Eun Hur, Soung Shin Shim, Kyung Soon Lee, Hye Sung Moon, Han Ki Yu, Hye Won Chung

Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans' University. Korea.

Abstract

OBJECTIVE
The present study was performed to evaluate the association of p53 codon 72 polymorphism and endometriosis. MATERIALS AND METHODS: We investigate 74 women who were operated for endometriosis and 93 women who had no endometriotic lesion proved by operation. Polymerase chain reaction was used to detect p53 codon polymorphisms. Result: We have found no significant difference between endometriosis and control group in the p53 codon polymorphism. The respective proportion of arginine homozygotes, heterozygotes and proline homozygotes in endometriosis group were 18.9%, 62.2% and 18.9%, respectively, and were 12.9%, 75.2% and 11.9%, respective in the group without endometriosis. CONCLUSION: Endometriosis is not associated with p53 polymorphism in Korean endometriosis patients.

Key Words: Endometriosis; p53; Polymorphism; Arginine; Proline