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Korean Journal of Fertility and Sterility 2006;33(2):97-104.
Published online June 1, 2006.
Association of the COMT Gene Polymorphism with the Risk of PCOS in Korean Women.
Ji Young Lee, Yun Jeong Cha, Seung Eun Hur, Han Sung Kwon, Sun Joo Lee, In Sook Sohn, Soo Nyung Kim, Yon A Seung, Hye Won Chung
1Department of Obstetrics and Gynecology, College of Medicine, Konkuk University, Seoul, Korea.
2Department of Obstetrics and Gynecology, College of Medicine, Konyang University, Daejun, Korea.
3Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Korea.
4Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans University, Seoul, Korea.
Abstract
OBJECTIVE
To investigate whether polymorphism of Catechol-O-methyltransferase (COMT) gene is associated with the risk of polycystic ovary syndrome (PCOS) in Korean women. METHODS: One hundred and thirty-six PCOS patients and eighty four controls were enrolled. Blood samples were collected from the patients diagnosed according to the 2003 revised criteria of the Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Age matched women with regular menstruation from same geographic region were recruited as control subject. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) of PCR products were done to determine all individuals' genotype. RESULTS: In women with COMT(LL) genotype, there was decreased PCOS risk and this difference was statistically significant (OR 0.24, 95% CI 0.11~0.51). CONCLUSION: The results suggest that the COMT(LL) genetic polymorphism might be associated with PCOS risk in Korean women.
Key Words: COMT; PCOS; Polymorphism


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