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Korean Journal of Fertility and Sterility 2004;31(1):51-57.
Published online March 1, 2004.
Association of the COMT Gene Polymorphism with the Risk of Endometriosis in Korean Women.
Sa Ra Lee, So Hyun Lee, Woon Jeong Lee, Sung Eun Hur, Ji Young Lee, Hye Sung Moon, Hye Won Chung
1Department of Obstetrics and Gynecology, College of Medicine, Ewha woman's University, Korea.
2Department of Obstetrics and Gynecology, Konkuk University Hospital. Seoul, Korea.
Abstract
OBJECTIVE
To investigate whether polymorphism of gene encoding COMT is associated with the risk of endometriosis in Korean women. METHODS: We investigated 136 patients with histopathologically confirmed endometriosis rAFS stage III/IV and 251 control group women who were surgically proven to have no endometriosis. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) of PCR products were done to determine each participant's COMT genotype. RESULTS: The distribution according to NIaIII genetic polymorphisms of COMT were as follows. COMT HH, COMT HL, and COMT LL genotypes were 56.6% (77 women), 34.6% (47 women) and 8.8% (12 women) in the study group and 50.6% (127 women), 39.4% (99 women) and 10.0% (25 women) in the control group. There was no significant difference between the study group and the control group. CONCLUSION: The results suggest that COMT genetic polymorphism may not be associated with the development of endometriosis in Korean women.
Key Words: Endometriosis; Genetic polymorphism; COMT; NIaIII


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