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Korean Journal of Fertility and Sterility 2006;33(2):85-95.
Published online June 1, 2006.
Association of the CYP1B1 Gene Polymorphism with the Risk of Advanced Endometriosis in Korean Women.
Yeon Jean Cho, Sung Eun Hur, Ji Young Lee, In Ok Song, Mi Kyoung Koong, Hye Sung Moon, Hye Won Chung
1Department of Obstetrics and Gynecology, Samsung Cheil Hospital and Women's Healthcare Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
2Department of Obstetrics and Gynecology, College of Medicine, Konyang University, Daechon, Korea.
3Department of Obstetrics and Gynecology, College of Medicine, Konkuk University, Seoul, Korea.
4Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans University, Seoul, Korea.
Abstract
OBJECTIVE
To investigate whether polymorphisms of gene encoding CYP1B1 is associated with the risk of endometriosis in Korean women. METHODS: We investigated 199 patients with histopathologically confirmed endometriosis rAFS stage III/IV and 183 control group women who were surgically proven to have no endometriosis. The genetic distribution of four different CYP1B1 polymorphisms at G119-T, G432-C, T449-C, and A453-G were analyzed by polymerase chain reaction (PCR) and restriction fragment length polymorphism of PCR products. RESULTS: We found no overall association between each individual CYP1B1 genotype and the risk of endometriosis. The odds ratio of genotype GG/GC+GG/TC+TT/AA compared to GG/CC/CC/AA (reference) was calculated as 2.06 with a 95% confidence interval of 1.003~4.216. CONCLUSIONS: This results suggest that CYP1B1 genetic polymorphism may be associated with development of endometriosis in Korean women.
Key Words: Endometriosis; CYP1B1; Genetic polymorphism


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