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Korean Journal of Reproductive Medicine 2008;35(4):267-274.
Published online December 1, 2008.
Association between Endometriosis and Human alpha2-Heremans Schmidt Glycoprotein (AHSG) Polymorphism.
Jin Ju Kim, Soo Jin Chae, Jong Mee Kim, Gyoung Hoon Lee, Young Min Choi, Sung Hoon Kim, Jung Ho Shin, Taek Hoo Lee, Jun Young Hur, Byoung Suk Lee, Sung Tack Oh, Kyu Sup Lee, Young Tack Lim
1Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Korea.
2Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Korea.
3Department of Obstetrics and Gynecology, Maria Fertility Hospital, Korea.
4Department of Obstetrics and Gynecology, Gachon University Gil Medical Center, Korea.
5Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Korea.
6Department of Obstetrics and Gynecology, Korea University College of Medicine, Korea.
7Department of Obstetrics and Gynecology, Kyungpook National University School of Medicine, Korea.
8Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Korea.
9Department of Obstetrics and Gynecology, Chonnam National University College of Medicine, Korea.
10Department of Obstetrics and Gynecology, Pusan National University College of Medicine and Medical Research Institute, Pusan National University, Korea.
11Department of Obstetrics and Gynecology, St Vincent's Hospital, College of Medicine, Catholic University of Korea, Korea.
Abstract
OBJECTIVE
To evaluate the relationship between advanced stage endometriosis and polymorphisms in alpha2-Heremans Schmidt glycoprotein (AHSG) gene in Korean women. METHODS: One-hundred thirty women with endometriosis stage III and IV, and 224 women without endometriosis were enrolled. In these patients, we determined AHSG gene polymorphisms by PCR and RFLP (restriction fragment length polymorphism) analysis. RESULTS: The genotype distribution of the AHSG gene polymorphism in the endometriosis group was not different from that of the control group (AHSG 1*1/AHSG 1*2/AHSG 2*2 frequencies were 56.2%/37.7%/6.2% and 55.8%/39.3%/4.9% for the endometriosis and control groups, respectively, p=.864). Also, the frequency of AHSG 2 haplotype was not different between endometriosis patients and controls (AHSG 1 haplotype /AHSG 2 haplotype rates were 75.0%/25.0% and 75.4%/24.6% for the endometriosis and control groups, respectively, p=0.894). CONCLUSION: AHSG gene polymorphism was not associated with the risk of advanced stage endometriosis in the Korean population.
Key Words: Endometriosis; AHSG; Polymorphism
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