A Case of Successful Pregnancy in Patient with Recurrent Spontaneous Abortion by Preimplantation Genetic Diagnosis Following IVF-ET.

Jeong,  Jin Seok; Yeon,  Gyu Sun; Chae,  Hee Dong; Cheon,  Yong Pil; Kim,  Chung Hoon; Kang,  Byung Moon; Chang,  Yoon Seok; Mok,  Jung Eun

In Vitro

Korean Journal of Fertility and Sterility 1998;25(2):135-140.
Published online January 1, 2001.

A Case of Successful Pregnancy in Patient with Recurrent Spontaneous Abortion by Preimplantation Genetic Diagnosis Following IVF-ET.

Jin Seok Jeong, Gyu Sun Yeon, Hee Dong Chae, Yong Pil Cheon, Chung Hoon Kim, Byung Moon Kang, Yoon Seok Chang, Jung Eun Mok

Abstract

It was reported that the etiologies of recurrent spontaneous abortion are immunologic factors, endocrinologic problems, anatomical abnormalities, genetic abnormalities, infection, and unexplained factors. Among those etiologic factors, genetic abnormalities occur in about 5% of the couples who experience recurrent spontaneous abortions, and most common parental chromosomal abnormality contributing to recurrent abortion is balanced translocation. The advent of in vitro fertilization (IVF), the development of skills associated with the handling of human embryo, and an explosion of knowledge in molecular biology have opened the possibility of early diagnosis of genetic disease in preimplantation embryos. Therefore preimplantation genetic diagnosis (PGD) is indicated for couples, infertile or not, at risk of transmitting a genetic disease. A case of successful pregnancy and term delivery by PGD using fluorescence in situ hybridization (FISH) technique in patient with recurrent spontaneous abortion due to balanced translocation is presented with brief review of literatures.