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Korean Journal of Fertility and Sterility 2001;28(2):105-110.
Published online June 1, 2001.
A Study of Protein S Deficiency in Antiphospholipid Syndrome.
Yoon Sung Nam, Nam Keun Kim, Myung Seo Kang, Do Yeon Oh, Kwang Yul Cha
1Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University, Pocheon, Korea.
2Department of Genetics, College of Medicine, Pocheon CHA University, Pocheon, Korea.
3Department of Clinical Pathology, College of Medicine, Pocheon CHA University, Pocheon, Korea.
4Department of Internal Medicine, College of Medicine, Pocheon CHA University, Pocheon, Korea.
Abstract
OBJECTIVE
To evaluate the abnormality of protein S in patients with recurrent spontaneous abortion due to antiphospholipid syndrome. MATERIALS AND METHOD: Antigen and activity of protein S were analyzed by enzyme immunoassay and clotting method, respectively. RESULTS: Of 18 patients with antiphospholipid syndrome, 4 patients were found to have no abnormality of protein S. There were 14 cases of protein S abnormality. Among them, there were 8 cases of type 1, 1 case of type 2, and 5 cases of type 3 protein S deficiency. CONCLUSION: So in the workup of patients with recurrent spontaneous abortion due to antiphospholipid syndrome, the evaluation for protein S is required.
Key Words: Antiphospholipid syndrome; Protein S deficiency


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