A Study of Factor XII Deficiency in Recurrent Spontaneous Abortion.

Nam,  Yoon Sung; Kim,  Nam Keun; Lee,  Su Man; Kang,  Myung Seo; Oh,  Doyeon; Cha,  Kwang Yul

Original Article

Korean Journal of Fertility and Sterility 2001;28(3):209-214.
Published online September 1, 2001.

A Study of Factor XII Deficiency in Recurrent Spontaneous Abortion.

Yoon Sung Nam, Nam Keun Kim, Su Man Lee, Myung Seo Kang, Doyeon Oh, Kwang Yul Cha

¹Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University, Pocheon, Korea.
²Department of Genetics, College of Medicine, Pocheon CHA University, Pocheon, Korea.
³Department of Clinical Pathology, College of Medicine, Pocheon CHA University, Pocheon, Korea.
⁴Department of Internal Medicine, College of Medicine, Pocheon CHA University, Pocheon, Korea.

Abstract

OBJECTIVE
To evaluate factor XII deficiency in patients with recurrent spontaneous abortion and its relation to aPTT. MATERIAL AND METHOD: Factor XII was analyzed by clotting method. RESULTS: Of 70 patients with recurrent spontaneous abortion, there were 35 cases of factor XII deficiency. Among them, there were only 3 cases of prolonged aPTT. CONCLUSIONS: It is still unclear whether factor XII deficiency is related to recurrent spontaneous abortion. Molecular approaches should be used to understand further the causal relationship. But based on this result, in the workup of patients with recurrent spontaneous abortion, factor XII should be included. aPTT is not likely to represent the abnormality of factor XII.

Key Words: Factor XII deficiency; aPTT; Recurrent spontaneous abortion