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Korean Journal of Reproductive Medicine 2010;37(3):239-244.
Published online September 1, 2010.
Comparison between GnRH Antagonist and Agonist Long Protocols in Poor Responders.
Ji Young Choi, Seung Yup Ku, Hoon Kim, Byung Chul Jee, Chang Suk Suh, Seok Hyun Kim, Young Min Choi, Jung Gu Kim, Shin Yong Moon
1Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul National University, Seoul, Korea.
2Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University, Seoul, Korea.
3Department of Obstetrics and Gynecology, Incheon Medical Center, Incheon, Korea.
The objective of this retrospective study was to compare the in vitro fertilization (IVF) outcomes of gonadotropinreleasing hormone (GnRH) agonist and GnRH antagonist protocols in poor responders. METHODS: A total of 172 cycles in subjects with less than 5 oocytes retrieved treated with either GnRH agonist long protocols or antagonist protocols were included. The outcome variables such as numbers of growing follicles and retrieved oocytes, and the fertilization rate were evaluated as the main outcome measures. RESULTS: There was no difference in regard to the numbers of growing follicles and oocytes, and fertilization rate between the two groups. E2 level on Day 7/8, mean gonadotropin dose, and the days of stimulation were shown to be statistically different (p<0.01, respectively). CONCLUSION: Considering that similar results were observed with less time and gonadotropin dose, GnRH antagonist protocol may be considered as a preferable choice over GnRH agonist protocols in poor responders.
Key Words: Poor responder; Gonadotropin-releasing hormone agonist; GnRH antagonist; Controlled ovarian hyperstimulation; in vitro fertilization


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