Prediction and Prevention of Ovarian Hyperstimulation Syndrome.

Kim,  Hye Ok; Kang,  Inn Soo

Review

Clinical and Experimental Reproductive Medicine 2010;37(4):293-305.
Published online December 1, 2010.

Prediction and Prevention of Ovarian Hyperstimulation Syndrome.

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Kwandong University School of Medicine, Seoul, Korea.

Abstract

Ovarian hyperstimulation syndrome (OHSS) is a life-threatening iatrogenic complication of ovulation induction. Before ovarian stimulation, identification of patients vulnerable to developing OHSS is necessary. And ovarian stimulation should be started with low doses of gonadotropin or GnRH antagonist protocol. During monitoring of ovarian stimulation with risk of OHSS, coasting, low doses hCG and GnRH agonist for triggering ovulation are considered. If severe OHSS is predicted, cycle cancellation and cryopreservation of all embryos should be considered to reduce late-onset OHSS and morbidity. And metformin and dopamine agonist for reducing OHSS are being proposed as a prophylactic treatment for OHSS.

Key Words: OHSS; Risk factors; Prevention; Metformin; Dopamine agonist