| Influence of Sperm Fertilizing Capacity on Embryonic Development and Pregnancy in in Vitro Fertilization. |
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Myung Geol Pang, Byeong Jun Jung, Shin Yong Moon |
1GenDix, inc., Korea.
2Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University, Korea.
3Department of Obstetrics and Gynecology, infertility Center, Seoul Women's Hospital, incheon, Korea.
4Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea. |
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| Abstract |
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OBJECTIVES: To assess the fertilizing capacity using sperm penetration assay (SPA) to predict the outcome of the in vitro fertilization-embryo transfer (iVF-ET) outcome. MATERIALS AND METHODS: Semen samples were provided by 129 patients undergoing iVF. We attempted to correlate the extent of sperm penetration under enhanced SPA protocol with the results of fertilization, cleavage, preimplantation embryo development, and pregnancy. RESULTS: Univariate analysis demonstrated a statistically significant correlation between fertilizing capacity and motility, kinetics, fertilization, cleavage and embryo development, and pregnancy rate. By logistic regression analysis, fertilizing capacity was found to be the only variable that was statistically significant with respect to pregnancy rate. Fertilizing capacity, cleavage rate and pregnant rate were significantly higher in pregnant group. However, the fertilization rates was comparable with both group. CONCLUSIONS: Lower fertilizing capacity could denote a poorer prognosis for establishing a pregnancy, even after satisfactory fertilization rate is achieved. |
| Key Words:
Fertilizing capacity; SPA; iVF-ET |
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