| Serum ${beta}$-endorphin during Human Menopausal Gonadotropin-Hyperstimulated Menstrual Cycles |
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Jung-Gu Kim, Shin-Yong Mun, Yoon-Seok Chang, Jin-Yong Lee |
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Department of Obstetrics and Gynecology, College of Medicine, Seoul National University |
| Human Menopausal Gonadotropin으로 과배란유도된 월경주기에서의 혈청 ${beta}$-endorphin에 과한 연구 |
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김정구, 문신용, 장윤석, 이진용 |
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서울대학교 의과대학 산부인과학교실 |
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| Abstract |
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It has been reported that endogenous opioid peptides play a role in the control of the reproductive function. The goal of this study was to evaluate changs in the serum levels of ${\beta}$-endorphin during hyperstimulated menstrual cycle and their relationship to serum prolactin levels. Serum ${\beta}$-endorphin and prolactin levels were measured during menstrual cycles of 10 normal cylic women hyperstimulated by human menopausal gonadotropin (HMG) and of 10 women by clomiphene/HMG among in vitro fertilization candidates. The results were summarized as follows. 1. In clomiphene/HMG hyperstimulated menstrual cycle the mean serum ${\beta}$-endorphin level insignificantly on 2 day before aspiration of oocyte compared to basal level and reached maximum level on 1 day after aspiration. 2. There was a significant peak of the mean serum ${\beta}$-endorphin level on 1 day before aspiration in HMG hyperstimulated menstrual cycle. 3. On the same day from aspiration, there was no significant differences in the mean serum ${\beta}$-endorphin levels between HMG and clomiphene/HMG hyperstimulated cycles. 4. No significant correlation was noted between serum ${\beta}$-endorphin levels and prolactin levels. |
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