| The Correlation Between the Preovulatory $E_2$ Pattern and Pregnancy Rate after in Vitro Fertilization-Embryo Transfer |
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Sang-Hoon Lee, Hoon Choi, Jung-Gu Kim, Shin-Yong Moon, Jin-Yong Lee, Yoon-Seok Chang |
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Department of Obstetrics and Gynecology, College of Medicine, Seoul National University |
| 인간난자의 체외수정에서 난포기의 Estradiol 반응도와 양상이 임신율과의 판계에 관한 연구 |
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이상훈, 최훈, 김정구, 문신용, 이진용, 장윤석 |
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서울대학교 의과대학 산부인과학교실 |
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| Abstract |
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Ninety-one patients with irreparable tubal disease underwent in Vitro Fertilization-Embryo Transfer (IVF-ET) in Seoul National University Hospital. Ovulation was stimulated in 104 cycles by human menopausal gonadotropin (HMG) or follicular stimulating hormone (FSH)/human chorionic gonadotropin (HCG). The patients were classified as high (>900 pg/ml), intermediate (400-900 pg/ml), or low (<400pg/ml) responder according to preovulatory $E_2$ response and four $E_2$ patterns were found. The overall pregnancy rate per cycle in this consecutive series was 11.5% (n=12). The number of preovulatory oocytes per cycle was higher significantly in intermediate and high responder group than in low responder group (P<0.01), While the number of immature oocytes per cycle significantly higher in low responder group than high and intermediate responder group (P<0.01). The pregnancy rate in each responder group was not signigicant. According to the $E_2$ pattern of response, there was no significant difference in number of the immature and preovulatory oocytes recovery per cycle. There was a apparently direct relationship between the preovulatory $E_2$ pattern and pre gnancy rate was noted. |
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