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Korean Journal of Fertility and Sterility 1987;14(2):109-118.
The Correlation Between the Preovulatory $E_2$ Pattern and Pregnancy Rate after in Vitro Fertilization-Embryo Transfer
Sang-Hoon Lee, Hoon Choi, Jung-Gu Kim, Shin-Yong Moon, Jin-Yong Lee, Yoon-Seok Chang
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University
인간난자의 체외수정에서 난포기의 Estradiol 반응도와 양상이 임신율과의 판계에 관한 연구
이상훈, 최훈, 김정구, 문신용, 이진용, 장윤석
서울대학교 의과대학 산부인과학교실
Ninety-one patients with irreparable tubal disease underwent in Vitro Fertilization-Embryo Transfer (IVF-ET) in Seoul National University Hospital. Ovulation was stimulated in 104 cycles by human menopausal gonadotropin (HMG) or follicular stimulating hormone (FSH)/human chorionic gonadotropin (HCG). The patients were classified as high (>900 pg/ml), intermediate (400-900 pg/ml), or low (<400pg/ml) responder according to preovulatory $E_2$ response and four $E_2$ patterns were found. The overall pregnancy rate per cycle in this consecutive series was 11.5% (n=12). The number of preovulatory oocytes per cycle was higher significantly in intermediate and high responder group than in low responder group (P<0.01), While the number of immature oocytes per cycle significantly higher in low responder group than high and intermediate responder group (P<0.01). The pregnancy rate in each responder group was not signigicant. According to the $E_2$ pattern of response, there was no significant difference in number of the immature and preovulatory oocytes recovery per cycle. There was a apparently direct relationship between the preovulatory $E_2$ pattern and pre gnancy rate was noted.


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