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Korean Journal of Fertility and Sterility 1987;14(2):127-137.
Luteal Phase Serum Estradiol and Progesterone in In Vitro Fertilization and Embryo Transfer
Jin-Yong Lee, Hak-Soon Kim, Jung-Gu Kim, Shin-Yong Moon, Yoon-Seok Chang
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University
인간난자의 체외수정 및 배아의 자궁내이식 후 황체기 혈청 난포호르몬 및 황체호르몬의 변동에 관한 연구
이진용, 김학순, 김정구, 문신용, 장윤석
서울대학교 의과대학 산부인과학교실
Abstract
Steroid hormone profiles during luteal phases after in vitro fertilization(IVF) and embryo transfer(ET) have been evaluated in 83 cycles stimulated by pure follicle-stimulating hormone/human menopausal gonadotropin/human chorionic gonadotropin, in which 13 patients became pregnant. Serum estradiol($E_2$) and progesterone($P_4$) levels were determined on days 2, 5, 7 and 9 after laparoscopic follicle aspiration. The follicular $E_2$ peak was slightly higher in pregnancies than in failures. Positive correlations were observed between the follicular $E_2$ peaks and the $P_4$ levels on days 5 and 7 of the luteal phase in pregnancies, but no correlation was found in failures. The $E_2$ and $P_4$ levels on days 5 and 7 of the luteal phase were significantly higher in pregnancies than in failures, but not different on days 2 and 9. Values of the $P_4/E_2$ ratio were similar between the two groups. The luteal phase durations were 12 to 19 days and no correlation was observed between the lengths of luteal phase and the luteal $E_2$ or $P_4$ concentrations. These data suggest that high $P_4$ levels in the mid-luteal phase, which have positive correlations with the follicular $E_2$ peaks, might have a favorable influence on the pregnancy success in human IVF.


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