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Korean Journal of Fertility and Sterility 1984;11(2):41-49.
Studies on the Cyclic AMP Concentration and Uterine Tissue Differentiation During the Early Pregnancy of Rats
Sung-Rye Kim1, Kyung-Za Ryu2, Wan-Kyoo Cho3
1College of Medicine, Ewha Womans University
2College of Medicine, Yonsei University
3College of Natural Science, Seoul National University
초기 임신기간중 흰쥐의 자궁조직 분화와 Cyclic AMP 농도에 관하여
김성례1, 유경자2, 조완규3
1이화여대 의과대학
2연세대 의과대학
3서울대 자연대 동물학과
It has been well known that ovarian steroids, estradiol and progesterone play an important role in the endometrial preparation for the implantation process. The present investigation was undertaken to correlate function of ovarian steroids with cAMP concentrations in uterine tissues of rat during the various stages of the preimplantation period. Rats ovariectomized on day 2 were treated with estradiol or/and progesterone on day 3 or on day 4 and cAMP concentrations in uterine tissues were determined by competitive protein - binding assay in control - and steroid treated - ovariectomized rats. The results obtained are as follows; 1. In control rats, cAMP concentrations in uterine tissues were decreased with preimplantation period proceeded whereas cAMP concentrations were increased and showed the highest levels on day 6 in ovariectomized rats. 2. In rats treated with progesterone only or progesterone with estradiol after ovariectomy, cAMP concentrations on day 6 were lower than those of ovariectomized control but higher than those of intact control rats while estradiol only treatment decreased cAMP concentrations on day 3 and day 6, compared with those from intact- and ovariectomized-controls. It is, therefore, concluded that the concentrations of cAMP in uterine tissues were lower in estrogen-treated rats than in ovariectomized rats, suggesting the involvement of cAMP in the regulation of uterine tissue differentiation.


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