| COH-IVF Outcomes for Infertile Patients With Borderline Ovarian Tumor After Conservative Treatment. |
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Hyun Joo Lee, Ka Yougng Ahn, Ho Suap Hahn, Chan Woo Park, Kwang Moon Yang, In Ho Lee, Tae Jin Kim, Kyung Taek Lim, Ki Heon Lee, Inn Soo Kang |
1Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center Kwandong University, College of Medicine, Seoul, Korea.
2Division of Reproductive Endocrinology & Infertility, Cheil General Hospital and Women's Healthcare Center Kwandong University, College of Medicine, Seoul, Korea.
3Division of Gynecology Oncology, Cheil General Hospital and Women's Healthcare Center Kwandong University, College of Medicine, Seoul, Korea. |
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| Abstract |
OBJECTIVE
To examine determinants of successful pregnancy and evaluate COH-IVF outcomes of infertile patients after conservative surgical treatment of borderline ovarian tumor (BOT). METHODS: In women of BOT (n=93), from January 1995 to December 1999, 44 of 93 women underwent conservative surgical treatment. From theses 44 women, patients characteristics, surgical and histological parameters were compared between 14 women who conceived and 30 women who failed to conceive. For 5 infertile women of 30 women who failed to conceive, 10 attempt IVF cycles were analysed; clinical pregnancy rate (CPR), implantation rate (IR) and live birth rate (LBR). RESULT: Women who conceived tend to be younger (25.9 vs 27.0 years) and lower serum CA-125 level (59.7 vs 72.9) compared to women who failed to conceive without significant difference. For 8 cycles out of 10 attempt IVF cycles, except for 2 cancellation cycles, the mean number of oocytes retrieved was 5.6 (range 2~16) with a mean fertilization rate of 74.4%. The CPR, IR and LBR per embryo transfer were 50.0% (4/8 cycles), 31.6% (6/19) and 50.0% (4/8 cycles) respectively. During the mean follow-up period after COH-IVF initiation, 29.6 (range 14~61) months, no recurrence was found. CONCLUSION: No determinant of successful pregnancy was found after conservative treatment for BOT. COH-IVF may be considered for infertile patients after conservative treatment of BOT. However, larger clinical studies with longer follow-up are necessary to evaluate the safety and efficacy of COH-IVF. All patients should be informed of the potential risks associated with ovarian hyperstimulation and close follow-up is necessary after COH-IVF. |
| Key Words:
ovarian tumors (BOT); Conservative surgical treatment; COH-IVF |
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