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Korean Journal of Reproductive Medicine 2008;35(1):69-76.
Published online March 1, 2008.
Relationship between FSH Receptor Genotype and Clinical Outcomes of IVF-ET in Infertile Korean Women.
Mi Hye Moon, Hye Won Choi, Min Jee Kim, Hyoung Song Lee, Sun Hwa Cha, In Ok Song, Mi Kyoung Koong, Jin Hyun Jun
1Laboratory of Reproductive Biology & Infertility, Cheil General Hospital & Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea.
2Department of Obstetrics and Gynecology, Cheil General Hospital & Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea.
Abstract
OBJECTIVE
The purposes of this study were to determine the distribution of follicle-stimulating hormone receptor (FSHR) genotypes in infertile Korean women and to evaluate the relationship between FSHR genotypes and clinical outcomes of IVF-ET cycles. METHODS: Genomic DNA was extracted from peripheral blood in 1,020 of infertile Korean women. Genotypes of FSHR at Thr307Ala (T/A) and Asn680Ser (N/S) were screened by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Clinical outcomes related to the genotypes of FSHR were evaluated in IVF-ET cycles (n=302) with controlled ovarian hyperstimulation (COH) of infertile women under 40 years old. RESULTS: In a population of 1,020 infertile Korean women, the frequency of TT/NN, TA/NS and AA/SS for the major variant Thr307Ala and Asn680Ser was 44.80%, 41.96% and 10.49%, respectively. There was no significant difference in characteristics of ovarian response and clinical pregnancy rate among the major genotypes of FSHR in IVF-ET cycles with COH. However, implantation rate of AA/SS patients was significantly higher than that of TT/NN patients (24.5% vs 15.7%, p<0.05). CONCLUSION: This study showed that FSHR genotype was not directly associated with ovarian response in IVF-ET cycles with COH. The relationship between clinical outcomes and FSHR genotypes of patients should be substantiated by further studies.
Key Words: Follicle-stimulating hormone receptor (FSHR); Genotype; Controlled ovarian hyperstimulation (COH); Ovarian response; Clinical outcome
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