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Korean Journal of Reproductive Medicine 2009;36(3):199-208.
Published online September 1, 2009.
Expression of Decidual Natural Killer (NK) Cells in Recurrent Abortion Patients with Increased Peripheral NK Cells.
Hyun Joo Lee, Sun Haeng Kim, Kwang Moon Yang, Dong Wook Park, Chan Woo Park, Sung Ran Hong, Dong Hee Cho, In Ok Song, Mi Kyoung Koong, Inn Soo Kang
1Department of Obstetrics & Gynecology, Cheil General Hospital & Women's Healthcare Center, Korea.
2Department of Obstetrics and Gynecology, School of Medicine, Korea University, Korea.
3Laboratory of Reproductive Biology & Infertility, School of Medicine, Korea University, Korea.
4Department of Pathology, School of Medicine, Korea University, Korea.
5Department of Clinical Pathology, School of Medicine, Korea University, Korea.
Abstract
OBJECTIVES: The purpose of this study was to compare the decidual NK cell populations between increased pre-conceptional peripheral NK cell population and normal pre-conceptional peripheral NK cell population in women with a history of recurrent abortion. METHODS: Fourteen women with history of recurrent abortion and elevated pre-conceptional peripheral NK cell, above 15% of peripheral lymphocyte population were included in this study. As a control, twelve women with history of recurrent abortion and their peripheral NK cell percentage showed below 15% were included. Distribution of CD56+ and CD16+ NK cells in paraffin embedded decidual tissues including implantation sites were examined by immunohistochemical staining using anti-CD56, 16 monoclonal antibodies. After immuohistochemical staining, the numbers of decidual NK cells were counted and compared these results between study and control groups. RESULTS: There was significant difference in decidual CD56+ NK cell count (170.1+/-132.1 vs. 68.3+/-66.1, p=0.02) between increased peripheral CD56+ NK cell group and control group. But, there showed no statistically significant correlation between decidual CD56+ NK cell count and peripheral CD56+ NK cell percentage (r=0.229, p=0.261). Also there was no statistically difference decidual CD16+ NK cell count between study and control group (25.70+/-11.72 vs. 31.17+/-22.67), and no correlation between decidual CD16+ NK cell and peripheral CD16+ NK cell percentage (r=-1.40, p=0.535). Conclusions: This study shows that decidual CD56+ NK cell are significantly increased in decidua of women exhibiting a history of recurrent abortion with increased CD56+ peripheral NK cell. This study suggests that the percentage of peripheral NK cell reflect the expression of decidual NK cell. Consequently, pre-conceptional peripheral blood NK cell population can be the useful marker for detecting the risk of subsequent miscarriage.
Key Words: Peripheral CD56+ NK cell; Decidual CD56+ NK cell; Recurrent abortion
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Expression of Decidual Natural Killer (NK) Cells in Women of Recurrent Abortion with Increased Peripheral NK Cells.2008 June;35(2)



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