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Korean Journal of Reproductive Medicine 2010;37(2):143-151.
Published online June 1, 2010.
The Optimal Time for Embryo Transfer in Fresh IVF: Comparison between Day 3 and Day 5 on Pregnancy Outcomes.
Sang Woo Lyu, Ari Kim, Hyun Ha Seok, You Shin Kim, Woo Sik Lee, Tae Ki Yoon, Hyung Jae Won
Fertility Center of CHA Gangnam Medical Center, Department of Obstetrics and Gynecology, CHA University College of Medicine, Seoul, Korea.
The aim of this study was to compare day 3 embryo transfer (D3ET) with day 5 ET (D5ET) in fresh in vitro fertilization (IVF) cycle on pregnancy outcomes. METHODS: We conducted a retrospective matched case control study that included 90 women with D3ET and 90 women with D5ET from January 2007 to June 2009. Subjects were matched for reproductive profiles and IVF cycle characteristics. Two good quality embryos were transferred in both groups. Pregnancy rates (PR), implantation rate, and multiple PR were compared. RESULTS: Demographics, stimulation parameters and embryological data were comparable in both groups. Main pregnancy outcomes with D3ET and D5ET groups were not statistically different: implantation rate (39.4% vs. 32.8%), positive PR (57.8% vs. 46.7%), clinical PR (53.3% vs. 45.6%), ongoing PR (50.0% vs. 42.2%), respectively. Both groups showed high multiple PR (37.5% vs. 34.1). CONCLUSION: D5ET may not be beneficial and necessary in comparison with D3ET on pregnancy outcomes, and elective single ET should be considered to decrease multiple pregnancies in women with favorable conditions and good quality embryos undergoing IVF.
Key Words: Embryo transfer; Cleavage stage; Blastocyst transfer; Pregnancy outcomes
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