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Korean Journal of Reproductive Medicine 2010;37(2):173-179.
Published online June 1, 2010.
A Case of Tamoxifen-Associated Rapid Growing and Multiple Endometrial Polyps.
Hee Jun Lee, Hoon Kim, Seung Yup Ku, Wonshik Han, Seok Hyun Kim, Young Min Choi, Jung Gu Kim, Shin Yong Moon
1Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
2Department of Obstetrics and Gynecology, Incheon Medical Center, Incheon, Korea.
3Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University, Seoul, Korea.
4Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.
Abstract
The antiestrogen tamoxifen is currently the most commonly used adjuvant treatment of breast cancer with antiestrogenic effect on mammary tissue. However, it is also associated with endometrial abnormalities, including hyperplasia, polyps, carcinoma, mostly interpreted as evidence of estrogenic effect on the endometrium. Previously, tamoxifen-associated polyp in breast cancer has been reported in the literature. Most studies had a long follow-up period and tamoxifen-associated polyp developed more than 1 year after tamoxifen treatment. In this case, we report an unusual case of rapid growing and multiple endometrial polyps that were developed only after 3 months' tamoxifen treatment in a postmenopausal breast cancer patient who received quadrant mastectomy with a brief review of literature.
Key Words: Tamoxifen; Endometrial polyp
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