A Case of Kallmann's Syndrome with Hypoplasia of Olfactory Bulb.

Nam,  Y S; Lee,  S H; Han,  S Y; Yoon,  T K; Cha,  K Y

Case Report

Korean Journal of Fertility and Sterility 1999;26(2):281-285.
Published online January 1, 2001.

A Case of Kallmann's Syndrome with Hypoplasia of Olfactory Bulb.

Y S Nam, S H Lee, S Y Han, T K Yoon, K Y Cha

Abstract

Kallmann's syndrome has both a general and specific connotation in describing general condition of gonadotropin-releasing hormone (GnRH) deficiency or a particular cluster of anomalies associated with primary eunuchoidism. The familial occurrence of hypogonadotropic hypogonadism associated with anosmia, color blindness, synkinesia, and mental defect is the classic Kallmann's syndrome. Interestingly, anosmia, or lack of smell, was not found in the absence of gonadal deficiency in the original study of this disorder. This disorder was found on both sexes, but the male to female ratio was 11:1, and Kallmann's syndrome is more often listed under disorders of male hypogonadism for this reason. Gross anatomy has shown disorders of the olfactory bulbs associated with Kallmann's syndrome and it was demonstrated a failure of GnRH-containing cells to migrate from the olfactory placode to the hypothalamus and preoptic area. We have experienced a case of Kallmann's syndrome which showed a hypoplasia of olfactory bulb in MRI during the workup of primary amenorrheic patient. So we report this case with a brief review of literatures.

TOOLS

PDF Links
Full text via DOI
Download Citation

Share :

METRICS

881 View
2 Download

Related articles in Clin Exp Reprod Med

A Case of Kallmann Syndrome Inherited in Autosomal Dominant Mode.1999 December;26(3)