Korean J Fertil Steril Search

CLOSE


Korean Journal of Fertility and Sterility 2000;27(1):83-90.
Published online January 1, 2001.
Changes in Profiles of Humoral Immune Facrors after Treatment of Gonadotropin Releasing Hormone Agonist in Patients with Endometriosis.
Jung Gu Kim, Shin Yong Moon, Soong Beom Kang, Jin Yong Lee, Dong Ho Kim, Doo Suck Choi, Dae Won Kim
Abstract
OBJECTIVE
S: To investigate the incidence of antiphospholipid antibodies in patients with proven endometriosis and apparently normal controls, and to evaluate the changes in profiles of humoral immune factors in endometriosis after treatment with gonadotropin releasing hormone agonist (GnRHa). METHODS: Sera of 92 patients with endometriosis, 40 patients without endometriosis and 128 normal male blood doners (normal controls) were tested for the presence of autoantibodies to six phospholipids (cardiolipin, phosphatidylserine, phosphatidyglycerol, phosphatidylethanolamine, phosphatidylinositol, phosphatidic acid) and beta 2-glycoprotein I(GPI)- dependent anticardiolipin antibodies. Also, antiendometrial antibodies (AEA), antiphospholipid antibodies (APA), Immunoglobulin (Ig)G, IgA, IgM, complement C3, C4 and CA-125 were measured in 26 endometriosis patients before and after 3 months of GnRHa treatment. RESULTS: Eighteen (19.6%) patients with endometriosis had at least one of the APA compared with normal controls (8.3%). The prevalence of beta 2-GPI-dependent anticardiolipin antibodies was higher in patients with endometriosis than in normal controls. There were no significant changes in the positivity and levels of AEA and APA after GnRHa Treatment and the levels of immunoglobulins and complement showed similiar pattern. However, the numbers of patients with the level of CA-125 > 35 IU/ml, which is defined as the upper limit of normal level and the levels of CA-125 decreased. CONCLUSIONS: Around 20% of patients with endometriosis had APA and CA-125 measurement may be better than humoral factor tests in monitoring patients with endometriosis after GnRHa treatment.
TOOLS
Share :
Facebook Twitter Linked In Google+ Line it
METRICS Graph View
  • 53 View
  • 0 Download
Related articles in Clin Exp Reprod Med


ABOUT
ARTICLE CATEGORY

Browse all articles >

BROWSE ARTICLES
AUTHOR INFORMATION
Editorial Office
Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital,
82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 13620, Korea
Tel: +82-31-787-7254    Fax: +82-31-787-4054    E-mail: blasto@snubh.org                

Copyright © 2019 by Korean Society for Reproductive Medicine. All rights reserved.

Developed in M2community

Close layer
prev next