The Analysis of LHbeta -subunit Variants in Infertile Patients with Premature Ovarian Failure (POF) in Korea.

Lee,  Eu Gene; Kim,  Nam Keun; Lee,  Sook Hwan; Ko,  Jung Jae; Cha,  Kwang Yul; Jeon,  Hye Sun; Lee,  Kyung Ah

Original Article

Korean Journal of Fertility and Sterility 2000;27(2):179-182.
Published online January 1, 2001.

The Analysis of LHbeta -subunit Variants in Infertile Patients with Premature Ovarian Failure (POF) in Korea.

Eu Gene Lee, Nam Keun Kim, Sook Hwan Lee, Jung Jae Ko, Kwang Yul Cha, Hye Sun Jeon, Kyung Ah Lee

Abstract

This study was performed to determine whether the LHbeta -subunit gene missense mutation is present in Korean infertile patients with 46,XX POF women. The variants of LHbeta exon 2 (Trp 8Arg; TGG to CGG and Ile15Thr; ATC ti ACC) were studied in forty-four 46.XX idiopathic POF and 54 nonpregnant women. The LHbeta exon 2 variants were more frequent in POF patients (20.5%) than nonpregnant( 16.7%) women (p>0.05). POF patients with the variant was slightly higher than nonpregnant women with the variant.