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Korean Journal of Fertility and Sterility 2002;29(4):279-286.
Published online December 1, 2002.
A Study of Estrogen only Therapy and Estrogen Plus Androgen Combination Therapy in Surgical Menopause Patients.
Kwang Bum Bai
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea.
Abstract
OBJECTIVE
To evaluate the difference between estrogen only therapy and estrogen-androgen combination therapy in surgical menopause patients. MATERIALS AND METHOD: Surgical menopause patients received 0.625 mg conjugated equine estrogens or 0.625 mg conjugated equine estrogens plus 1.25 mg methyltestosterone for 2 years. Bone mineral density, menopausal symptoms, lipoprotein profiles were measured. RESULTS: Both groups showed increased bone mineral density. In the combination group, total cholesterol, high density lipoprotein cholesterol and triglycerides decreased. In the estrogen only group, low density lipoprotein cholesterol decreased but high density lipoprotein cholesterol increased significantly. In both groups, menopausal symptoms were much improved. Side effects were easily tolerated in both groups. CONSLUSIONS: Estrogen-androgen combination therapy had comparable benefits compared with estrogen only therapy.
Key Words: Estrogen-androgen therapy; Surgical menopause
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