| The Effect of Isoflavone Supplementation on Plasma Biochemical Parameters of Women with Polycystic Ovary Syndrome. |
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Hyung Jae Won, Ju Hee Kang, Min Jun Lee, Sun Yoon, Ki Hyun Park, Dong Je Cho, Chan Ho Song, Byung Seok Lee |
1Department of Obstetrics and Gynecology, Yong dong Severance Hospital, Yonsei University, College of Medicine, Seoul, Korea.
2Department of Food and Nutrition, The graduate School of Yonsei University, Seoul, Korea. |
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| Abstract |
OBJECTIVE
This study was performed to evaluate the effect of isoflavone supplementation on hormone levels, lipid profiles and total antioxidant status in patients with polycystic ovary syndrome. METHODS: Total 11 women with polycystic ovary syndrome were supplemented daily with 150mg of isoflavone for 6 months. Blood samples were collected 0, 3, and 6 months after supplement of isoflavone for analysis of LH, FSH, E2, testosterone, free testosterone, SHBG levels, serum lipid profiles, and total antioxidant status (TAS). RESULTS: After 6 months isoflavone supplementation, the hormone levels did not change significantly. Serum lipid profiles did not show any significant change in total cholesterol, LDL-cholesterol, triglyceride, lipoprotein(a), and free fatty acid levels. However, there was significant increase in HDLcholesterol (p<0.05) for 3 months. Total antioxidant status was increased significantly after isoflavone supplementation for 6 months (p<0.05). CONCLUSION: Isoflavone supplementation showed positive effects on the HDL-cholesterol and total antioxidant status. it is implicated that isoflavone supplementation will may have a effect on cardiovascular disease in patients with polycystic ovary syndrome. |
| Key Words:
Isoflavone; Polycystic ovary syndrome; Hormone levels; Lipid profiles; Total antioxidant status |
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