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Korean Journal of Fertility and Sterility 2005;32(1):55-63.
Published online March 1, 2005.
Clinical Outcomes of Frozen-thawed Embryo Transfer after Microsurgical Removal of Damaged Blastomere.
Won Yun Choi, Jie Ohn Sohn, Eun A Park, Dong Ryul Lee, Woo Sik Lee, Se Yul Han, Lee Suk Park, Jung Hyun Cho, Soo Hee Kim, Kwang Yul Cha, Tae Ki Yoon
Fertility Center of CHA General Hospital, CHA Research Institute, Pochon CHA University, Seoul, Korea.
Abstract
OBJECTIVE
Human infertility clinics have been faced the demand for improving clinical results. The purpose of this study was to evaluate the effect of microsurgical removal of damaged blastomeres (DB) in frozen-thawed embryos on the clinical outcomes. METHODS: From January 2003 to May 2004, out of 258 thawing ET cycles were divided into three groups: Group-1 (n=46): Intact cleavaged embryos after thawing. Remained cycles with embryos containing DB were randomly divided into two groups. Group-2 (n=102): Drilling zona pellucida (ZP) of frozen-thawed embryos by acidified Tyrode's solution. Group-3 (n=110): Drilling ZP and removal of DB. Embryos after microsurgical manipulation were transferred into the uterus of patients. RESULTS: Clinical profiles and the mean number of transferred embryos among three groups were not different. Pregnancy and implantation rates were similar in three groups. It were 30.4% and 9.3% in Group-1, 29.4% and 7.8% in Group-2, and 26.4% and 7.6% in group-3, respectively. Miscarriage rate in Group-3 (37.9%) was slightly higher than those in Group-1 and Group-2 (14.3% and 23.3%), but it was not statistically significant. CONCLUSION: Intact cleaving embryos after DB removal showed higher potent of pregnancy and implantation. We could not find any improvement of clinical outcome by removal of DB in frozen-thawed embryos.
Key Words: Damaged blastomeres (DB); Microsurgical removed; Frozen-Thawed embryo; Pregnancy rate


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