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Korean Journal of Fertility and Sterility 2006;33(3):149-157.
Published online September 1, 2006.
The Clinical Efficiency of Clomiphene Citrate vs Clomiphene Citrate/GnRH Antagonist on Infertile Women with Normal Ovulatory Cycles.
Woo Seok Lee, Jae Hong Sang, Jae Joon Kim, Gwang June Kim, Dong Ho Kim, Sang Hun Lee
Department of Obstetrics and Gynecology, College of Medicine, Chung-Ang University, Seoul, Korea.
Abstract
OBJECTIVE
This study was to investigate the clinical efficiency of clomiphene citrate/GnRH antagonist protocol comparing with the clomiphene citrate only protocol in infertile women with normal ovulatory cycles. METHOD: Among 116 patients, 43 were received assisted reproductive technologies using natural ovulatory cycle, 38 and 35 were received clomiphene citrate only protocol and clomiphene citrate/GnRH antagonist combined protocol, respectively, and the clinical results were compared and analyzed. RESULTS: In each group, basal levels of LH, FSH, E2 and FSH, E2 on hCG day injected were not different, but LH level and endometrial thickness on hCG injected day were decreased significantly and the pregnancy rate was increased significantly in clomiphene citrate/GnRH antagonist group. CONCLUSION: The pregnancy rate was increased significantly in clomiphene citrate/GnRH antagonist group compared with natural ovulatory cycle and clomiphene citrate only group.
Key Words: Clomiphene citrate; GnRH antagonist
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