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Korean Journal of Fertility and Sterility 2006;33(3):159-170.
Published online September 1, 2006.
Risk Factors Related to Uterine Leiomyoma in Korean Women: A Retrospective Study.
D G Hong, M J Chung, B S Kim, J M Lee, Y L Cho, T H Lee, S S Chun
Department of Obstetrics and Gynecology, Kyungpook National University, School of Medicine, Daegu, Korea.
The purpose of this study is to find out risk factors related to uterine leiomyoma in Korean women and to compare with the results of previous western studies. METHODS: A retrospective analysis was carried out. All the cases of uterine leiomyoma (n=244) were diagnosed surgically or sonographically between Jannuary 1998 and December 2004. Total of 269 controls not having uterine leiomyoma were collected from patients who visited Kyungpook national university hospital for routine gynecologic check-up or treatment of their gynecologic or obstetric diseases other than uterine leiomyoma. Data were collected through review of medical records and interviews and analyzed with chi-square and logistic regression model. RESULTS: In multivariate analysis, patient's age (OR 1.070; 95% Cl 1.041~1.099), number of artificial abortion (OR 1.182; 95% Cl 1.018~1.374) and alcohol drinking (OR 1.865; 95% Cl 1.231~2.824) had significantly positive correlation with uterine leiomyoma. The duration of lactation was the only factor which had negative correlation (OR 0.985; 95% Cl 0.972~0.998). BMI, parity, age at menarche, the duration and interval of menstruation, caffeine consumption and marital status did not show any correlations. CONCLUSION: In this study, patient's age, number of artificial abortion, and alcohol drinking were the risk factors of uterine leiomyoma in Korean women and the result was similar to that of western studies. Though we couldn't find out the specific risk factors related to the development of uterine leiomyoma in this study, but it has a great meaning to be the first trial in Korean women. The role of information bias should be carefully evaluated and further multicentered, randomized, controlled prospective studies will be needed to know the possible risk factors among Korean women.
Key Words: Uterine leiomyoma; Risk factor; Korean women
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