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Korean Journal of Fertility and Sterility 2006;33(4):245-251.
Published online December 1, 2006.
Mitochondrial DNA Copy Number in the Patients of Korean Polycystic Ovary Syndrome (PCOS).
Ji Eun Park, Min Hee Jang, Sung Won Cho, Yoo Shin Kim, Hyung Jae Won, Jung Hyun Cho, Kwang Hyun Baek, Sook Hwan Lee
1Fertility Center of CHA General Hospital, CHA Research Institute, Pochon CHA University, Korea.
2"Genome Research Center for Infertility and Reproductive Medicine" of Korea Ministry of Health & Welfare, Korea.
Abstract
OBJECTIVE
We analyzed quantification of mitochondria DNA (mtDNA) to investigate the relationship of mitochondria and pathogenesis of PCOS. MATERIALS AND METHODS: Peripheral blood samples were collected from 28 patients with PCOS who were under the inclusion criteria for PCOS and from 28 healthy controls. Genomic DNA was used to analyze real-time PCR for mtDNA copy number quantification. The mtDNA copy number was compared between the control and PCOS groups. All data was expressed as mean +/- SD. Statistical analysis was assessed by t-test. RESULTS: In this study, the mtDNA CT was 11.67+/-0.422 in PCOS patients and 11.51+/-0.722 in control group, respectively. The mtDNA copy number was 1726410.71+/-407858.591 the patients of in PCOS and 2167887.51+/-252459.28 in control group (p=0.08), respectively. CONCLUSION: In our study, using real-time PCR, there was a tendency of lower mtDNA copy number in the patients of PCOS when comparing to the control group even though statistical difference was not significant. However, more extensive analysis is required to clarity relationship between mtDNA copy number and pathogenesis of PCOS.
Key Words: PCOS; Mitochondria; Real-time PCR


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