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Korean Journal of Fertility and Sterility 1980;7(1):3-10.
Neuroendocrine Control of Pituitary Gonadotropin Release
Kyung-Za Ryu
Department of Pharmacology, Yonsei University College of Medicine
뇌하수체(腦下垂體) 성선자극(性腺刺戟)호르몬 분비(分泌)의 신경내분비적(神經內分泌的) 조절(調節)
연세대학교 의과대학 약리학교실
Pituitary gonadotropes, as target cells, exhibit cyclic changes in terms of LH and FSH release in synchrony with the estradiol levels. The ultimate release is determined by the relative size of the two pools of gonadotropins, which is regulated by the two controllers: LH-RH and estradiol. LH-RH appears to serve as a primary drive on the gonadotrope, stimulating gonadotropin synthesis, storage, and release. Estradiol amplifies the action of LH-RH and induces the development of a self-priming effect of LH-RH except that it impedes LH-RH mediated gonadotropin release. Negative and positive feedback action of estradiol is revealed to operate by different mechanisms. The pituitary capacity increases severalfold from early to late follicular phase, which is considered to be prerequisite for the development of mid-cycle surge. CNS-hypothalamic dopamine, norepinephrine, and prostaglandins, as well as LH-RH, are involved in the negative and positive feedback effects of estradiol. The possible mechanisms in the triggering of LH-RH release for the initiation of midcycle LH-RH surge are considered.
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