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Korean Journal of Reproductive Medicine 2009;36(1):55-61.
Published online March 1, 2009.
Clinical Outcome of IVF-ET using Testicular Sperm Retrieved from Patients with Obstructive Azoospermia or Hypospermatogenesis.
Sang Chul Han, Yong Seog Park, Su Jin Choi, Sun Hee Lee, Seung Bum Hong, Hyoung Song Lee, Chun Kyu Lim, In Ok Song, Ju Tae Seo
1Laboratory of Reproductive Biology and Infertility, Cheil General Hospital & Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea.
2Department of Obsterics and Gynecology, Cheil General Hospital & Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea.
3Department of Urology, Cheil General Hospital & Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea.
Abstract
OBJECTIVE
To compare the clinical outcomes of ICSI with sperm retrieved from testicular tissue in patients with obstructive azoospermia (OA) or hypospermatogenesis (HS). METHODS: From January 2003 through December 2006, 155 patients with OA (241 cycles) and 28 patients with HS (34 cycles) were included in this study. We compared clinical outcomes of ICSI with testicular sperm such as fertilization rate, implantation rate, clinical pregnancy rate and delivery rate. Data were statistically analyzed using t-test and chi-square -test. RESULTS: Testicular spermatozoa could not be retrieved in 1 out of the 21 cycles where fresh testicular sperm extraction in HS patients. Fertilization rate (FR) was significantly higher in OA than HS (75.6 % vs. 62.6%, p<0.001). Cleavage rate (CR) per fertilized zygote was also significantly higher in OA than that in HS (66.8% vs. 54.8% p<0.001). However, there were no significant differences in good embryo rate (GER), clinical pregnancy rate (CPR), implantation rate (IR) and delivery rate (DR). CONCLUSION: Our results show that testicular sperm of HS does not affect CPR, IR, and DR although it has shown reduced FR and CR.
Key Words: Obstructive azoospermia; Hypospermatogenesis; Testicular spermatozoa; ICSI


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