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Korean Journal of Reproductive Medicine 2010;37(3):231-237.
Published online September 1, 2010.
Predominant T Helper 1 Immune Response in Women with Reproductive Failures.
Ae Ra Han, Kwang Moon Yang, Joanne Kwak Kim
1Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Cheil General Hospital & Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea.
2Reproductive Medicine, Department of Obstetrics and Gynecology, Chicago Medical School at Rosalind Franklin University of Medicine and Science, Chicago, IL, USA.
To evaluate whether T helper 1 (Th1) immune response is predominant in women with reproductive failures (recurrent spontaneous abortion and recurrent implantation failure) and the activation of T cell is related to Th1 propensity. METHODS: Women with a history of recurrent implantation failure or recurrent spontaneous abortion comprise the study group (n=37). Controls are normal fertile women without a history of infertility or pregnancy losses (n=11). Th1/Th2 ratios of interferon (INF)-gamma/interleukin (IL)-10 and tumor necrosis factor (TNF)-alpha/IL-10 expression on CD3+/4+ cells, CD154, and CD69 expression on T cells are measured by flow cytometric analysis. RESULTS: The ratios of TNF-alpha to IL-10 expressing on CD3+/4+ cells (Th1/Th2 cell ratios) are significantly higher in study group (42.1+/-2.3) as compared with that of controls (28.7+/-2.7) (p=0.002). The overall trend of CD154 and CD69 expression on T cells are elevated in study group than those of controls. The proportion (%) of CD3+/4+/154+ cells (1.7+/-0.5 vs. 0.3+/-0.2, p=0.038) and the % of CD3+/8+/154+ cells (0.6+/-0.2 vs. 0.1+/-0.0, p=0.024) are significantly higher in study group. The % of CD3+/69+ cells (5.6+/-1.9 vs. 1.3+/-5.4, p=0.046) and % of CD3+/8+/69+ cells (4.8+/-1.3 vs. 1.8+/-0.2, p=0.035) among CD3+/8+ cells are significantly increased in study group. CONCLUSION: Women with reproductive failures have Th1 propensity with increased T cell activation. These finding means that activated T cell has a harmful effect on early pregnancy and implantation by induction of Th1 immunity.
Key Words: T cell activation; T helper 1 immunity; Reproductive failure
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