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Korean Journal of Fertility and Sterility 2001;28(3):247-247.
Published online September 1, 2001.
The Analysis of Methylenetetrahydrofolate Reductase Mutation in Recurrent Spontaneous Abortion.
Yoon Sung Nam, Kwang Yul Cha, Nam Keun Kim, Sun Hee Kim, Jin Woo Lim, Geum Duk Kang, Myung Seo Kang, Se Hyun Kim, Doyeun Oh
1Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University, Sungnam, Korea.
2Institute for Clinical Research, College of Medicine, Pocheon CHA University, Sungnam, Korea.
3Department of Biological Science, Ajou University, Suwon, Korea.
Abstract
OBJECTIVE
To analyze the methylenetetrahydrofolate reductase (MTHFR) mutation in patients with recurrent spontaneous abortion. MATERIAL AND METHOD: The blood samples of patients with recurrent spontaneous abortion were tested by PCR-RFLP method. RESULTS: Of 51 cases of study group, 14 (27.5%) were normal, 25 (49.0%) were heterozygosity, and 12 (23.5%) were homozygosity. Of 58 cases of control group, 20 (34.5%) were normal, 30 (51.7%) were heterozygosity, and 8 (13.8%) were homozygosity. But the difference between two groups was not significant (p=0.190). CONCLUSION: Hyperhomocysteinemia due to MTHFR mutation is a cause of recurrent spontaneous abortion. Therefore, the study for MTHFR mutation should be included in the workup of recurrent spontaneous abortion.
Key Words: Recurrent spontaneous abortion; MTHFR mutation


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