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Korean Journal of Fertility and Sterility 2002;29(1):29-35.
Published online March 1, 2002.
A Study of Lupus Anticoagulants and Anticardiolipin Antibodies in Patients with Infertility and Recurrent Spontaneous Abortion.
Yoon Sung Nam, Kwang Yul Cha, Jin Young Baek, Nam Keun Kim, Myung Seo Kang, Doyeon Oh
1Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University, Pocheon, Korea.
2Department of Clinical Pathology, College of Medicine, Pocheon CHA University, Pocheon, Korea.
3Institute for Clinical Research, College of Medicine, Pocheon CHA University, Pocheon, Korea.
Abstract
OBJECTIVE
To report the prevalence of lupus anticoagulants and anticardiolipin antibodies in patients with recurrent spontaneous abortion and infertility. MATERIAL AND METHOD: Lupus anticoagulants and anticardiolipin antibodies were analyzed by Diluted Russell's Viper Venom Test (DRVVT) and solid phase enzyme immunoassay, respectively. RESULTS: In 200 patients with infertility, there were 6 cases (3%) with positive lupus anticoagulants or anticardiolipin antibodies. Of these, 3 patients (1.5%) showed positive lupus anticoagulants and anticardiolipin antibodies, respectively. In 120 patients with recurrent spontaneous abortion, there were 13 cases (10.8%) of positive lupus anticoagulants or anticardiolipin antibodies. Of these, one patient (1%) showed lupus anticoagulants and 12 patients (10%) showed anticardiolipin antibodies. But in two groups, there was no cases with positive lupus anticoagulants and anticardiolipin antibodies. CONCLUSION: Lupus anticoagulants and anticardiolipin antibodies are definite cause of recurrent spontaneous abortion. There has been a speculation that they might be associated with infertility and repeated IVF failures. But it was found that the role of lupus anticoagulants and anticardiolipin antibodies in these cases are not clear.
Key Words: Lupus anticoagulants; Anticardiolipin antibodies; Recurrent spontaneous abortion; Infertility


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