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Korean Journal of Fertility and Sterility 2005;32(4):325-330.
Published online December 1, 2005.
The Histologic Features of the Uterus and Adnexa Extirpated from Gender Identity Disorder Patients with Depot Androgen Injection.
Jae Chun Byun, Bong Gyu Kwak, Ji Hyun Shin, Moon Seok Cha, Myoung Seok Han, Seo Hee Rha, Seok Kwun Kim
1Department of Obstetrics and Gynecology, College of Medicine, Dong-A University, Busan, Korea.
2Department of Pathology, College of Medicine, Dong-A University, Busan, Korea.
3Department of Plastic Surgery, College of Medicine, Dong-A University, Busan, Korea.
To investigate the histologic features of the uterus and adnexae extirpated from gender identity disorder (GID) patients that received depot androgen injection. METHODS: We reviewed the histologic findings of the uterus and adnexae removed from sixteen GID patients, who had taken depot androgen injection for 5~168 months. RESULTS: Fourteen patients (87.5%) showed the atrophied epithelium of exocervix and all of 16 patients (100%) showed the atrophy of endometrium. Seven patients (43.7%) showed multiple cystic follicles in the ovarian cortex and 6 patients (37.5%), 3 patients (18.7%) showed corpus albicans and corpus luteum, respectively. CONCLUSIONS: Exogenous androgen induced atrophy of cervix and endometrium. This effect was more prominent in the endometrium. In addition, PCO-like histologic features were observed in the ovary.
Key Words: Gender identity disorder (GID); Androgen therapy; Atrophy
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