Effect of Pentoxifylline on the ICSI Program Undergone in Severe Asthenozoospermia.

Sohn,  Jie Ohn; Shin,  Ji Su; Jeong,  Chang Jin; Cho,  Yong Seon; Oum,  Ki Boong; Choi,  Dong Hee; Kim,  Hyun Joo

Original Article

Korean Journal of Fertility and Sterility 2002;29(2):97-103.
Published online June 1, 2002.

Effect of Pentoxifylline on the ICSI Program Undergone in Severe Asthenozoospermia.

Jie Ohn Sohn, Ji Su Shin, Chang Jin Jeong, Yong Seon Cho, Ki Boong Oum, Dong Hee Choi, Hyun Joo Kim

Abstract

OBJECTIVE
The aim of this study was to evaluate the effect of Pentoxifylline(PF) on the conventional ICSI program undergone in severe asthenozoospermia. METHOD: Total 348 cycles of ICSI programs undertaken at CHA General Hospital from January, 1996 to September, 2000, were divided into two groups - injected with pentoxifylline-treated sperm(PFT, 204 cycles) or non-treated sperm(NPFT, 144 cycles) and the clinical results of PFT group were compared with those of NPFT. RESULTS: PF-treatment on sperm increased their motility of normozoospermia and severe asthenozoospermia. Fertilization rate of PFT group was higher than those of ICSI programs undertaken using sperm of NPFT(70.6% vs. 62.9%, p<0.01). And, ET and clinical pregnancy rates of PFT were slightly higher than those of NPFT(93.1%, 44.2% vs. 90.3%, 36.2%). CONCLUSION: These results showed that treatment of pentoxifylline has a beneficial role on selection of viable sperm in severe asthenozoospermia.