Successful Pregnancy by ICSI using Spermatozoa Banked Prior to Bone Marrow Transplantation for Severe Apalstic Anemia and Chronic Myelogenous Leukemia.

Han,  Jee Eun; Chung,  Tae Gyu; Chung,  Mi Kyung; Min,  Woo Sung; Lee,  Sook Hwan; Yoon,  Tae Ki

Case Report

Korean Journal of Fertility and Sterility 2003;30(2):185-188.
Published online June 1, 2003.

Successful Pregnancy by ICSI using Spermatozoa Banked Prior to Bone Marrow Transplantation for Severe Apalstic Anemia and Chronic Myelogenous Leukemia.

Jee Eun Han, Tae Gyu Chung, Mi Kyung Chung, Woo Sung Min, Sook Hwan Lee, Tae Ki Yoon

¹Department of Obstetrics and Gynecology, CHA General Hospital, College of Medicine, Pochon CHA University, Seoul, Korea.
²Department of Urology, CHA General Hospital, College of Medicine, Pochon CHA University, Seoul, Korea.
³Infertility Medical Center, CHA General Hospital, College of Medicine, Pochon CHA University, Seoul, Korea.
⁴Department of Internal Medicine, College of Medicine, Catholic University, Seoul, Korea.

Abstract

OBJECTIVE
To report tow cases of successful pregnancies following long term cryopreserved spermatozoa prior to bone marrow transplantation (BMT) for chronic myelogenous leukemia (CML) and severe aplastic anemia (SAA). MATERIALS AND MEHTODS: Case report. RESULTS: With the first case, after cryopreservation of semen from 25 year-old man with CML prior to BMT, his wife is being pregnant by intracytoplasmic sperm injection (ICSI) using thawed spermatozoa. With the second case, 28 year-old man with SAA became father by ICSI using banked spermatozoa before BMT. CONCLUSION: These cases support that men with malignancy have the chance of fathering their own genetic children. It is important therefore, to increase the awareness of clinicians especially oncologists and patients themselves to the new developments in preserving fertility for cancer patients.

Key Words: Semen cryopreservation; ART; ICSI; CML; SAA