| Nonspecific Empirical Medical Therapy with Acetylcarnitine Effective in Oligoasthenospermic Men?. |
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Jong Woo Kim, Jae Seok Lee, Jeong Su Park, Won Tae Kim, Ju Tae Seo |
1Department of Urology Sungkyunkwan University School of Medicine, Seoul, Korea.
2Department of Urology, Bundang Jesaeng Hospital, Seongnam, Korea. |
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| Abstract |
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PURPOSE: To determine the efficacy of CarnitilR (acetylcarnitine, Hanmi, Korea) therapy in idiopathic oligoasthenospermic men. MATERIALS AND METHODS: Forty-four subfertile men with abnormal semen parameters were treated between March, 2003 and March, 2004 with 3 g of CarnitilR daily for 3 months. Changes in semen parameters were evaluated 3 months after this therapy. RESULTS: The mean age was 34.2 years and the mean follow-up duration was 3.7 months. In asthenospemic patients (n=28), semen analysis before and after CarnitilR treatment showed an increase in volume (2.64+/-1.65 ml vs. 3.10+/-1.60 ml), motility (35.1+/-17.7% vs. 45.9+/-20.4%) and viability (51.4+/-20.3% vs. 59.3+/-13.6%) respectively. In oligoasthenospermic patients (n=16), semen analysis before and after CarnitilR treatment showed an increase in sperm count (10.7+/-54.4 million/ml vs. 38.4+/-32.5 million/ml) respectively. CONCLUSIONS: These results suggested that in idiopathic oligoasthenospermic men the empirical medical therapy with acetylcarnitine may be considered as primary treatment. |
| Key Words:
Carnitine; Acetylcarnitine; Male infertility |
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