Luteal Phase Serum Estradiol and Progesterone in In Vitro Fertilization and Embryo Transfer |
Jin-Yong Lee, Hak-Soon Kim, Jung-Gu Kim, Shin-Yong Moon, Yoon-Seok Chang |
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University |
인간난자의 체외수정 및 배아의 자궁내이식 후 황체기 혈청 난포호르몬 및 황체호르몬의 변동에 관한 연구 |
이진용, 김학순, 김정구, 문신용, 장윤석 |
서울대학교 의과대학 산부인과학교실 |
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Abstract |
Steroid hormone profiles during luteal phases after in vitro fertilization(IVF) and embryo transfer(ET) have been evaluated in 83 cycles stimulated by pure follicle-stimulating hormone/human menopausal gonadotropin/human chorionic gonadotropin, in which 13 patients became pregnant. Serum estradiol($E_2$) and progesterone($P_4$) levels were determined on days 2, 5, 7 and 9 after laparoscopic follicle aspiration. The follicular $E_2$ peak was slightly higher in pregnancies than in failures. Positive correlations were observed between the follicular $E_2$ peaks and the $P_4$ levels on days 5 and 7 of the luteal phase in pregnancies, but no correlation was found in failures. The $E_2$ and $P_4$ levels on days 5 and 7 of the luteal phase were significantly higher in pregnancies than in failures, but not different on days 2 and 9. Values of the $P_4/E_2$ ratio were similar between the two groups. The luteal phase durations were 12 to 19 days and no correlation was observed between the lengths of luteal phase and the luteal $E_2$ or $P_4$ concentrations. These data suggest that high $P_4$ levels in the mid-luteal phase, which have positive correlations with the follicular $E_2$ peaks, might have a favorable influence on the pregnancy success in human IVF. |
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