Clin Exp Reprod Med > Volume 50(1); 2023 > Article |
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Study origin (year) | Study population | Toxicant (dose) | Propolis dose | Duration | Effects on semen quality | Reference |
---|---|---|---|---|---|---|
Turkey (2021) | Male Sprague-Dawley rats | Cisplatin (3 mg/kg) | 100 mg/kg | 21 days | (+) Sperm motility | [29] |
Malaysia (2020) | Male Sprague-Dawley rats | Streptozotocin (60 mg/kg) | 300 mg/kg | 28 days | (+) Motility | [30] |
(+) Normal forms of sperm | ||||||
(+) Sperm count | ||||||
(+) Vitality | ||||||
(–) Sperm DNA damage | ||||||
Egypt (2020) | Adult male Sprague-Dawley rats | Paclitaxel (5 mg/kg) | 50 mg/kg | 28 days | (+) Motility | [31] |
(+) Count | ||||||
(+) Viability | ||||||
(–) Sperm abnormality | ||||||
(–) Sperm DNA damage | ||||||
India (2017) | Male mice | Mitomycin C (2, 4, and 8 mg/kg body weight) | 400 mg/kg | 35 days | (+/–) Sperm Motility | [32] |
(+/–) Sperm morphology | ||||||
(+/–) Sperm count | ||||||
(–) Sperm DNA damage | ||||||
Egypt (2010) | Male New Zealand white rabbits | Triphenyltin (0.5 mg/kg body weight) | 50 mg/kg | Daily for 84 days | (+) Sperm | [33] |
(+) Concentration | ||||||
(+) Sperm motility | ||||||
(+) Normal forms of sperm | ||||||
Egypt (2009) | Male rats | Aluminum chloride (34 mg/kg body weight) | 50 mg/kg | Daily for 70 days | (+) Sperm concentration | [34] |
(+) Sperm motility | ||||||
(+) Vitality | ||||||
(+) Normal forms of sperm | ||||||
Turkey (2016) | Male albino rats | Cadmium (1 mg/kg/day) | 50 mg/kg | 17 days | NA | [35] |
Turkey (2020) | Male Sprague-Dawley rats | Copper (128 mg/kg) | 100 mg/kg | 21 days | (+) Sperm motility | [36] |
(+) Sperm concentration | ||||||
(–) Abnormal sperm | ||||||
Egypt (2014) | Male Wistar albino rats | Doxorubicin (6 doses at 18 mg kg) | 200 mg/kg (5 day/wk) | 21 days | (+) Sperm count | [37] |
Italy (2006) | Human ejaculated sperm | Benzo[a]pyrene (500 µM) | 6, 12, and 25 µg/mL | 1 hour | (–) Sperm DNA damage | [38] |
Toxicant (dose) | Study population | Propolis dose (duration) | Mechanisms of the actions of propolis in the presence of toxicant | Reference |
---|---|---|---|---|
Cisplatin (3 mg/kg) | Male rats | 100 mg/kg (21 days) | (+) Testicular GSH, CAT, GPx, and Bcl2 | [29] |
(–) Testicular MDA and Bax | ||||
Streptozotocin (60 mg/kg) | Male rats | 300 mg/kg (28 days) | (+) Testicular testosterone and serum testosterone | [30] |
(+) mRNA of AR and LH receptor | ||||
(+) StAR, CYP11A1, CYP17A1, 3β-HSD and 17β-HSD proteins | ||||
(+) Testicular MCT2, MCT4, and mRNA of LDHc | ||||
Paclitaxel (5 mg/kg) | Adult male rats | 50 mg/kg/day (28 days) | (–) Testicular DNA damage | [31] |
(+) Testicular GSH content | ||||
Mitomycin C (2, 4, and 8 mg/kg BW) | Male mice | 400 mg/kg (35 days) | (+) Testicular testosterone | [32] |
(+) Inhibin B level | ||||
(–) Testicular oxidative stress | ||||
Triphenyltin (0.5 mg/kg BW) | Male rabbits | 50 mg/kg (84 days) | (+) Plasma testosterone | [33] |
(+) Weights of epididymis and testes | ||||
(+) Seminal plasma glutathione S-transferase | ||||
(+) Seminal plasma phosphatases and transaminases | ||||
(–) Seminal plasma TBARS | ||||
(–) Seminal plasma LDH | ||||
Aluminum chloride (34 mg/kg BW) | Male rats | 50 mg/kg (70 days) | (+) Plasma testosterone | [34] |
(+) Plasma 17-ketosteroid reductase | ||||
(+) Testicular GST and CAT | ||||
(+) Testicular GSH | ||||
Cadmium (1 mg/kg/day) | Male rats | 50 mg/kg (17 days) | (–) Number of apoptotic cells in the testes | [35] |
(–) HIF-1α expression | ||||
(+/–) Serum testosterone | ||||
Copper (128 mg/kg) | Male rats | 100 mg/kg/day (21 days) | (+) Testicular SOD, CAT, GSH | [36] |
(+) Johnsen's testicular score | ||||
(+) Spermatogenesis activity | ||||
(–) Testicular MDA | ||||
(–) Number of apoptotic cells in the testes | ||||
Doxorubicin (6 doses at 18 mg/kg) | Male rats | 200 mg/kg (5 day/wk) (21 days) | (+) Testicular interleukin-4 content | [37] |
(+) Testicular GSH | ||||
(–) Testicular MDA | ||||
(–) Testicular myeloperoxidase and caspase-3 | ||||
(–) Testicular TNFα and Fas-L | ||||
(–) Number of apoptotic cells in the testes | ||||
Benzo[a]pyrene (500 µM) | Human ejaculated sperm | 6, 12, and 25 µg/mL (1 hour) | (–) H2O2-induced oxidation in sperm | [38] |
(–) TBARS formation in sperm | ||||
(–) LDH release in sperm | ||||
CCl4 (3 mL/kg/day) | Adult male albino rats | 200 mg/kg/day (28 days) | (+) Serum testosterone | [46] |
(–) Testicular MDA | ||||
(+) Testicular GSH | ||||
(+) Testicular GPx, CAT, and SOD | ||||
(–) Testicular TNFα gene expression | ||||
(–) Testicular inflammation | ||||
Nω-nitro-l-arginine methyl ester (l-NAME) (40 mg/kg/day, for 15 days) | Hypertensive male rats | 200 mg/kg (5 days) | (+) Testicular MDA | [55] |
(–) Testicular CAT | ||||
(+/–) Nitric oxide ([+] with only propolis)) |
GSH, glutathione; CAT, catalase; GPx, glutathione peroxidase; Bcl2, B-cell lymphoma 2; MDA, malonyl dialdehyde; BAX, BCL2 associated X protein; AR, androgen receptor; LH, luteinizing hormone; StAR, steroidogenesis acute regulatory protein; CYP11A1, cytochrome P450 A1; CYP17A1, cytochrome P450 17A1; HSD, hydroxysteroid dehydrogenase; MCT, monocarboxylate transporter; LDHc, lactate dehydrogenase type C; BW, body weight; TBARS, thiobarbituric acid-reactive substances; LDH, lactate dehydrogenase; GST, glutathione-S-transferase; HIF-1α, hypoxia-inducible factor 1-alpha; SOD, superoxide dismutase; TNFα, tumor necrosis factor alpha; Fas-L, Fas ligand.
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