Clin Exp Reprod Med > Volume 49(4); 2022 > Article |
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Study | Study design | No. of evaluated embryos | Origin of embryos | Time-lapse monitoring system | Identified predictive marker |
---|---|---|---|---|---|
Wong et al. (2010) [20] | Retrospective study | 100 | Supernumerary frozen 2PN | Modified Olympus IX-70/71; CKX-40/41 BioStation CT | First cytokinesis, P2 and P3 |
Hashimoto et al. (2012) [21] | Experimental study | 80 | Donated human embryos for research | BioStation CT | Durations of second and third mitotic divisions |
Hlinka et al. (2012) [22] | Retrospective study | 180 | Clinical IVF routine | Primo vision | c2, c3, and c4; i2, i3, and i4 |
Cruz et al. (2012) [23] | Retrospective cohort study | 834 | Oocyte donation cycles | EmbryoScope | t4, s2, DC3 cells, and tM; UN2 cells |
Chamayou et al. (2013) [24] | Retrospective study | 224 | Fresh oocyte ICSI cycles | EmbryoScope | t1, t2, t4, t7, t8, tC–tF, and s3 |
Kirkegaard et al. (2013) [25] | Prospective cohort study | 571 | Fresh oocyte ICSI cycles | EmbryoScope | First cytokinesis, t3, and DC3 cells |
Conaghan et al. (2013) [26] | Prospective multicenter study | 233 | Fresh oocyte ICSI cycles | Eeva | P2 and P3 |
Kirkegaard et al. (2014) [27] | Prospective multicenter study | 1,519 | Fresh oocyte ICSI cycles | EmbryoScope | P2 and P3 |
Cetinkaya et al. (2015) [28] | Retrospective observational cohort study | 3,354 | Clinical IVF routine | EmbryoScope | CS2 |
Yang et al. (2015) [29] | Prospective observational study | 345 | Metaphase I donated for research | Primo vision | Cleavage patterns |
Milewski et al. (2015) [30] | Prospective observational study | 432 | Fresh oocyte ICSI cycles | EmbryoScope | t2, t5, cc2, and SC |
Storr et al. (2015) [31] | Prospective cohort study | 380 | Fresh oocyte ICSI cycles | EmbryoScope | s3, t8, and tEB |
Motato et al. (2016) [32] | Retrospective study | 7,483 | Clinical IVF routine | EmbryoScope | tM and t8–t5 |
Coticchio et al. (2018) [33] | Retrospective observational study | 500 | Fresh oocyte ICSI cycles | EmbryoScope | PN appearance during fertilization |
Zaninovic et al. (2019) [34] | Retrospective multicenter study | 27,316 | Fresh oocyte ICSI cycles | EmbryoScope | t3, t3-t2, t5, t3-tPNF and t5-tPNF |
Desai et al. (2019) [35] | Retrospective observational study | 716 | Fresh oocyte ICSI cycles | EmbryoScope | Cleavage patterns |
PN, pronuclei; CT, computed tomography; P2, time of division from 2 to 3 cells; P3, time of division from 3 to 4 cells; IVF, in vitro fertilization; c2, time between 3 and 4 cells; c3, time between 5 and 8 cells; c4, time between 9 and 16 cells; i, interphase; t4, time of cleavage to 4 cells; s2, the second synchronization parameter (t4–t3); DC, direct cleavage; tM, time from insemination to compaction into the morula stage; UN, uneven blastomere size; ICSI, intracytoplasmic sperm injection; t1, time of cleavage to 1 cell; t2, time of cleavage to 2 cells; t7, time of cleavage to 7 cells; t8, time of cleavage to 8 cells; tC–tF, time of pronuclei appearance to disappearnace; s3, the third synchronization parameter (t8–t5); t3, time of cleavage to 3 cells; CS2, cleavage synchronicity from 2 cell; t5, time of cleavage to 5 cells; cc2, the second round of cleavage (t3–t2); SC, s_t2×odds ratios_t2+s_t5×odds ratios_t5+s_cc2×odd ratios_cc2; tEB, time from insemination to expanded blastocyst; tPNf, time from insemination to pronuclei fading.
Study | Study design | No. of evaluated embryos | Origin of embryos | Time-lapse monitoring system | Identified predictive marker |
---|---|---|---|---|---|
Lemmen et al. (2008) [36] | Retrospective study | 19 | IVF/ICSI cycles | Nikon Diaphot 300 microscope with camera in a closed system | Nuclei appearance in the first blastomere |
Meseguer et al. (2011) [37] | Retrospective study | 247 | ICSI cycles | EmbryoScope | t5, s2, cc2, UN 2 cell, MN 4 cell, and DC 1–3 cells |
Azzarello et al. (2012) [38] | Prospective study | 159 | ICSI cycles | EmbryoScope | PN breakdown |
Hlinka et al. (2012) [22] | Retrospective study | 114 | ICSI cycles | Primo Vision | c2, c3 and c4; i2, i3, and i4 |
Rubio et al. (2012) [39] | Retrospective multicenter study | 5,225 (1,659 transferred) | IVF cycles from donated and autologous oocytes | EmbryoScope | DC 2–3 cells |
Freour et al. (2013) [40] | Retrospective analysis and prospectively collected database | 191 | ICSI cycles | EmbryoScope | t4 and s3 |
Chamayou et al. (2013) [24] | Retrospective study | 178 | ICSI cycles | EmbryoScope | cc3 |
Kirkegaard et al. (2013) [25] | Prospective cohort study | 84 | ICSI cycles | EmbryoScope | None |
Rubio et al. (2014) [41] | Prospective randomized control trial | 2,638 | ICSI cycles from donated oocytes | EmbryoScope | t5, s2, cc2, UN 2 cell, MN 4 cell, and DC 1–3 cells |
Aguilar et al. (2014) [42] | Retrospective cohort study | 1,448 | ICSI cycles from donated oocytes | EmbryoScope | Time to 2PB, PF, and length of S-phase |
Basile et al. (2015) [43] | Retrospective multicenter study | 1,122 | ICSI cycles from donated and autologous oocytes | EmbryoScope | cc2, t3, t5, UN 2 cell, MN 4 cell, and DC 1–3 cells |
Vermilyea et al. (2014) [44] | Retrospective multicentric study | 331 | IVF/ICSI cycles | Eeva | P2 and P3 |
Freour et al. (2015) [45] | Retrospective study | 528 | ICSI cycles | EmbryoScope | t5, s2, cc2, UN 2 cell, MN 4 cell, and DC 1–3 cells |
Dominguez et al. (2015) [46] | Retrospective cohort study | 28 | ICSI cycles from donated oocytes | EmbryoScope | cc2 |
Adamson et al. (2016) [47] | Prospective concurrent cohort study | ICSI and IVF cycles from autologous oocytes | Eeva | P2 and P3 | |
Goodman et al. (2016) [48] | Prospective randomized control trial | 2,092 | ICSI and IVF cycles from autologous oocytes | EmbryoScope | cc2, s2, t5, s3, tSB, MN, and irregular division |
Coello et al. (2017) [49] | Retrospective observational cohort study | 429 | ICSI cycles | EmbryoScope | Vitrified/warmed blastocyst morphology and collapse pattern |
Zaninovic et al. (2019) [34] | Retrospective multicenter study | 816 | Fresh oocyte ICSI cycles | EmbryoScope | t3–t2 |
Barberet et al. (2019) [50] | Retrospective cohort study | 232 | ICSI cycles | EmbryoScope | PN appearance and MN 2cells |
IVF, in vitro fertilization; ICSI, intracytoplasmic sperm injection; t5, time of cleavage to 5 cells; s2, the second synchronization parameter (t4–t3); cc2, the second round of cleavage (t3–t2); UN, uneven blastomere size; MN, multinucleated; DC, direct cleavage; PN, pronuclei; c2, time between 3 and 4 cells; c3, time between 5 and 8 cells; c4, time between 9 and 16 cells; i, interphase; t4, time of cleavage to 4 cells; s3, the third synchronization parameter (t8–t5); cc3, the third round of cleavage (t8–t4); PB, polar body; PF, time of pronuclei fading; t3, time of cleavage to 3 cells; P2, time of division from 2 to 3 cells; P3, time of division from 3 to 4 cells; tSB, time of starting blastulation.
Study | Study design | No. of evaluated embryos | Time-lapse monitoring system | Biopsy day after fertilization | Analysis methods of PGD | Identified predictive marker |
---|---|---|---|---|---|---|
Chavez et al. (2012) [60] | Prospective observational study | 75 | Custom-built microscope | Day 3 | aCGH | P1, P2, P3, and fragmentation |
Campbell et al. (2013) [61] | Retrospective cohort study | 98 | EmbryoScope | Day 5 | aCGH/SNP array | tSB and tB |
Basile et al. (2014) [62] | Retrospective cohort study | 504 | EmbryoScope | Day 3 | aCGH | t5–t2 and cc3 |
Rienzi et al. (2015) [63] | Longitudinal cohort study | 455 | EmbryoScope | Day 5 | CCS | None |
Chawla et al. (2015) [64] | Retrospective cohort study | 460 | EmbryoScope | Day 3 | aCGH | tPNf, t2, t5, cc2, cc3, and t5–t2 |
Vera-Rodriguez et al. (2015) [65] | Prospective observational study | 85 | Eeva | Day 3 | aCGH | Time between PN disappearance and the start of 1st cytokinesis; 3 to 4 cell |
Mumusoglu et al. (2017) [66] | Retrospective cohort study | 415 | EmbryoScope | Day 5 | aCGH | t9, tM, tSB, tB, and tEB, |
Desai et al. (2018) [67] | Retrospective analysis of prospectively collected data | 767 | EmbryoScope | Day 5 | aCGH/NGS | Dysmorphisms, tSB, tEB, and tEB-tSB |
Rocafort et al. (2018) [68] | Retrospective study | 1,482 | Eeva | Day 5 | NGS | P2 and P3 |
Huang et al. (2019) [69] | Retrospective observational study | 188 | EmbryoScope | Day 5 | aCGH | Starting time to blastocyst expansion |
Yap et al. (2019) [70] | Retrospective study | 807 Patients | EmbryoScope | Day 5 | NGS | KIDscore D5 algorithm (score 6.0–9.9) |
Gazzo et al. (2020) [71] | Retrospective study | 492 | EmbryoScope | Day 5 | NGS | KIDscore D5 algorithm |
Ozbek et al. (2021) [72] | Retrospective analysis of prospectively collected data | EmbryoScope | Day 5 | NGS | Cleavage patterns | |
Urich et al. (2022) [73] | Prospective observational study | 212 | EmbryoScope | Day 5 | NGS | t2 and t3 |
De Gheselle et al. (2022) [74] | Retrospective cohort study | 539 | EmbryoScope | Day 5 | NGS | tPB2, tPNa, and t7 |
PGD, preimplantation genetic diagnosis; aCGH, array-based comparative genomic hybridization; P1, time of division from 1 to 2 cells; P2, time of division from 2 to 3 cells; P3, time of division from 3 to 4 cells; SNP, single-nucleotide polymorphism; tSB, time of stating blastulation; tB, time from insemination to formation of a full blastocyst; t5, time of cleavage to 5 cells; t2, time of cleavage to 2 cells; CCS, comprehensive chromosome screening; tPNf, time from insemination to pronuclei fading; cc2, the second round of cleavage (t3–t2); cc3, the third round of cleavage (t8–t4); PN, pronuclei; t9, time of cleavage to 9 cells; tM, time from insemination to compaction into the morula stage; tEB, time from insemination to expanded blastocyst; NGS, next-generation sequencing; tPB2, time of 2nd polar body extrusion; tPNa, time from insemination to pronuclei appearance; t7, time of cleavage to 7 cells.
Male factor infertility and in vitro fertilization-embryo transfer.1992 June;19(1)